"GeneDx"[submitter] AND "LRRK2"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 58210	GRCh38/hg38 12q12(chr12:39651727-41240339)x3	CNTN1, LINC01779 +25 more	Copy number gain	See cases	GUncertain significance
Select item 1297877	NC_000012.12:g.40224884T>C	LINC01779, LOC130007688 +1 more	Single nucleotide variant	not provided	GBenign
Select item 1196141	NC_000012.12:g.40224903G>A	LINC01779, LOC130007688 +1 more	Single nucleotide variant (genic upstream transcript variant)	not provided	GLikely benign
Select item 369016	NM_198578.4(LRRK2):c.-124G>C	LRRK2, LOC130007688	Single nucleotide variant (5 prime UTR variant)	not provided +1 more	GBenign/Likely benign
Select item 1268980	NM_198578.4(LRRK2):c.152-56G>A	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1274942	NM_198578.4(LRRK2):c.152-50G>A	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1810504	NM_198578.4(LRRK2):c.182A>G (p.His61Arg)	LRRK2 (H61R)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 39147	NM_198578.4(LRRK2):c.225G>A (p.Ala75=)	LRRK2	Single nucleotide variant (synonymous variant)	Inborn genetic diseases +2 more	GBenign/Likely benign
Select item 1248412	NM_198578.4(LRRK2):c.237+100A>G	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1199754	NM_198578.4(LRRK2):c.237+239A>G	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1194715	NM_198578.4(LRRK2):c.238-278G>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 308610	NM_198578.4(LRRK2):c.344A>C (p.His115Pro)	LRRK2 (H115P)	Single nucleotide variant (missense variant)	not provided +1 more	GBenign/Likely benign
Select item 1296540	NM_198578.4(LRRK2):c.347A>G (p.Gln116Arg)	LRRK2 (Q116R)	Single nucleotide variant (missense variant)	not provided +1 more	GBenign/Likely benign
Select item 496937	NM_198578.4(LRRK2):c.347+2T>C	LRRK2	Single nucleotide variant (splice donor variant)	not provided +1 more	GConflicting classifications of pathogenicity
Select item 1287690	NM_198578.4(LRRK2):c.347+45T>C	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1285921	NM_198578.4(LRRK2):c.347+100C>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1211258	NM_198578.4(LRRK2):c.347+193A>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 2430901	NM_198578.4(LRRK2):c.352del (p.Ile118fs)	LRRK2 (I118fs)	Deletion (frameshift variant)	not provided	GUncertain significance
Select item 39167	NM_198578.4(LRRK2):c.356T>C (p.Leu119Pro)	LRRK2 (L119P)	Single nucleotide variant (missense variant)	not provided +1 more	GConflicting classifications of pathogenicity
Select item 1280061	NM_198578.4(LRRK2):c.436+38A>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1179306	NM_198578.4(LRRK2):c.436+120T>A	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1216078	NM_198578.4(LRRK2):c.436+231C>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1181395	NM_198578.4(LRRK2):c.436+271A>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1280363	NM_198578.4(LRRK2):c.437-163G>A	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1220701	NM_198578.4(LRRK2):c.437-145AACA[5]	LRRK2	Microsatellite (intron variant)	not provided	GBenign
Select item 1194511	NM_198578.4(LRRK2):c.437-44T>G	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1327197	NM_198578.4(LRRK2):c.437-38A>C	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 39192	NM_198578.4(LRRK2):c.457T>C (p.Leu153=)	LRRK2	Single nucleotide variant (synonymous variant)	not provided +1 more	GBenign
Select item 1313483	NM_198578.4(LRRK2):c.478T>A (p.Phe160Ile)	LRRK2 (F160I)	Single nucleotide variant (missense variant)	not provided +2 more	GUncertain significance
Select item 1268977	NM_198578.4(LRRK2):c.571+33T>C	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1272742	NM_198578.4(LRRK2):c.571+194T>G	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1285904	NM_198578.4(LRRK2):c.571+195C>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1266896	NM_198578.4(LRRK2):c.572-127T>C	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1183494	NM_198578.4(LRRK2):c.707-189T>C	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1203376	NM_198578.4(LRRK2):c.707-58C>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 2499353	NM_198578.4(LRRK2):c.751A>G (p.Asn251Asp)	LRRK2 (N251D)	Single nucleotide variant (missense variant)	Autosomal dominant Parkinson disease 8 +1 more	GUncertain significance
Select item 1196994	NM_198578.4(LRRK2):c.838+177T>C	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1255039	NM_198578.4(LRRK2):c.839-160C>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 308612	NM_198578.4(LRRK2):c.867C>T (p.Asn289=)	LRRK2	Single nucleotide variant (synonymous variant)	Autosomal dominant Parkinson disease 8 +1 more	GBenign/Likely benign
Select item 1296583	NM_198578.4(LRRK2):c.958+299A>C	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1178615	NM_198578.4(LRRK2):c.958+323G>A	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1247444	NM_198578.4(LRRK2):c.959-282A>G	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1227216	NM_198578.4(LRRK2):c.959-216dup	LRRK2	Duplication (intron variant)	not provided	GBenign
Select item 1211778	NM_198578.4(LRRK2):c.959-216del	LRRK2	Deletion (intron variant)	not provided	GLikely benign
Select item 1265912	NM_198578.4(LRRK2):c.959-160C>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1878959	NM_198578.4(LRRK2):c.959-61G>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 308613	NM_198578.4(LRRK2):c.1102-10C>A	LRRK2	Single nucleotide variant (intron variant)	not provided +1 more	GBenign
Select item 1190290	NM_198578.4(LRRK2):c.1181+244T>C	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1228934	NM_198578.4(LRRK2):c.1181+250A>G	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1250049	NM_198578.4(LRRK2):c.1181+284G>A	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 308614	NM_198578.4(LRRK2):c.1182-4A>G	LRRK2	Single nucleotide variant (intron variant)	Autosomal dominant Parkinson disease 8 +1 more	GBenign/Likely benign
Select item 452768	NM_198578.4(LRRK2):c.1246C>T (p.Gln416Ter)	LRRK2 (Q416*)	Single nucleotide variant (nonsense)	not provided	GLikely pathogenic
Select item 39131	NM_198578.4(LRRK2):c.1256C>T (p.Ala419Val)	LRRK2 (A419V)	Single nucleotide variant (missense variant)	LRRK2-related condition +2 more	GBenign/Likely benign
Select item 1235419	NM_198578.4(LRRK2):c.1288+130G>A	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1207632	NM_198578.4(LRRK2):c.1289-333C>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1187789	NM_198578.4(LRRK2):c.1289-248_1289-246del	LRRK2	Deletion (intron variant)	not provided	GLikely benign
Select item 1230794	NM_198578.4(LRRK2):c.1418+72A>G	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1203966	NM_198578.4(LRRK2):c.1418+129T>C	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1199692	NM_198578.4(LRRK2):c.1419-286C>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 39135	NM_198578.4(LRRK2):c.1517G>A (p.Arg506Gln)	LRRK2 (R506Q)	Single nucleotide variant (missense variant)	not provided +1 more	GLikely benign
Select item 1212986	NM_198578.4(LRRK2):c.1543+283C>A	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1238652	NM_198578.4(LRRK2):c.1543+307C>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1222062	NM_198578.4(LRRK2):c.1544-54A>G	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 39139	NM_198578.4(LRRK2):c.1653C>G (p.Asn551Lys)	LRRK2 (N551K)	Single nucleotide variant (missense variant)	not provided +1 more	GBenign
Select item 1255038	NM_198578.4(LRRK2):c.1656+68C>G	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1200075	NM_198578.4(LRRK2):c.1656+165A>C	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1211173	NM_198578.4(LRRK2):c.1656+171A>G	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1238571	NM_198578.4(LRRK2):c.1740A>T (p.Leu580Phe)	LRRK2 (L580F)	Single nucleotide variant (missense variant)	not provided +1 more	GBenign
Select item 1242954	NM_198578.4(LRRK2):c.1802-11dup	LRRK2	Duplication (intron variant)	not provided +1 more	GBenign
Select item 1304112	NM_198578.4(LRRK2):c.1817G>A (p.Gly606Asp)	LRRK2 (G606D)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 1211772	NM_198578.4(LRRK2):c.1941+39C>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1222726	NM_198578.4(LRRK2):c.1942-272C>A	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1206522	NM_198578.4(LRRK2):c.1942-114T>C	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1786100	NM_198578.4(LRRK2):c.2110A>G (p.Met704Val)	LRRK2 (M704V)	Single nucleotide variant (missense variant)	Inborn genetic diseases +1 more	GConflicting classifications of pathogenicity
Select item 39144	NM_198578.4(LRRK2):c.2134A>G (p.Met712Val)	LRRK2 (M712V)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 39146	NM_198578.4(LRRK2):c.2167A>G (p.Ile723Val)	LRRK2 (I723V)	Single nucleotide variant (missense variant)	not provided +1 more	GBenign
Select item 1296670	NM_198578.4(LRRK2):c.2242-93G>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1239386	NM_198578.4(LRRK2):c.2242-22C>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 39148	NM_198578.4(LRRK2):c.2264C>T (p.Pro755Leu)	LRRK2 (P755L)	Single nucleotide variant (missense variant)	not provided +1 more	GBenign/Likely benign
Select item 39149	NM_198578.4(LRRK2):c.2378G>T (p.Arg793Met)	LRRK2 (R793M)	Single nucleotide variant (missense variant)	not provided +1 more	GConflicting classifications of pathogenicity
Select item 1791041	NM_198578.4(LRRK2):c.2422T>A (p.Phe808Ile)	LRRK2 (F808I)	Single nucleotide variant (missense variant)	not provided +1 more	GUncertain significance
Select item 39150	NM_198578.4(LRRK2):c.2428A>G (p.Ile810Val)	LRRK2 (I810V)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 1231524	NM_198578.4(LRRK2):c.2500+142del	LRRK2	Deletion (intron variant)	not provided	GBenign
Select item 1207633	NM_198578.4(LRRK2):c.2500+166C>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1202999	NM_198578.4(LRRK2):c.2500+211G>C	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1268516	NM_198578.4(LRRK2):c.2501-236T>C	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1249671	NM_198578.4(LRRK2):c.2501-212A>G	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1274621	NM_198578.4(LRRK2):c.2501-96C>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 308617	NM_198578.4(LRRK2):c.2501-9dup	LRRK2	Duplication (intron variant)	not provided +2 more	GBenign
Select item 705830	NM_198578.4(LRRK2):c.2594C>T (p.Ser865Phe)	LRRK2 (S865F)	Single nucleotide variant (missense variant)	not provided +1 more	GBenign/Likely benign
Select item 1712592	NM_198578.4(LRRK2):c.2684G>A (p.Ser895Asn)	LRRK2 (S895N)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 1218717	NM_198578.4(LRRK2):c.2689+73A>G	LRRK2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1258299	NM_198578.4(LRRK2):c.2689+145A>G	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1263620	NM_198578.4(LRRK2):c.2690-312C>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1262301	NM_198578.4(LRRK2):c.2690-251C>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1278220	NM_198578.4(LRRK2):c.2690-65A>T	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 706064	NM_198578.4(LRRK2):c.2761G>A (p.Val921Ile)	LRRK2 (V921I)	Single nucleotide variant (missense variant)	not provided +1 more	GLikely benign
Select item 39153	NM_198578.4(LRRK2):c.2769G>C (p.Gln923His)	LRRK2 (Q923H)	Single nucleotide variant (missense variant)	not provided +1 more	GConflicting classifications of pathogenicity
Select item 1249316	NM_198578.4(LRRK2):c.2808+189A>G	LRRK2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1289422	NM_198578.4(LRRK2):c.2808+233_2808+234del	LRRK2	Microsatellite (intron variant)	not provided	GBenign

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